The genome is highly organized structure that undergoes dynamic rearrangements linked to its functions or in response to various stimuli (e.g. epigenetic). Understanding this complex structure is a fundamental step to comprehending gene expression and regulation as well as genome repair and stability; in a more general way to discovering the genetic basis for health and disease.
DNA is wrapped around histones to form nucleosome themselves compacted into chromatin. This compaction of DNA and proteins is certainly among the most complex structure to study due to its high heterogeneity in sequence and 3D structure and represent an ideal candidate for super-resolution microscopy and SMLM in particular. Indeed, Abbelight’s technologies are suitable for OligoSTORM and OligoDNA-PAINT (1, 2) approaches to visualize 3D structure of genomic regions.
Abbelight’s solution are also well suited to visualize DNA replication sites or to characterize Nuclear pore complex (NPC) structure which also plays an important role in genome regulation (3)
